Hetriva Rivastigmine Transdermal Patch for Dementia & Alzheimer’s

Use K-Plast for:

• Post-surgery pain
• Muscle aches, sprains, or strains
• Chronic pain that lasts all day

Storage & Precautions:

• Storage: Keep in a cool, dry place, away from direct sunlight and heat.
• Precautions:
  • For external use only.
  • Avoid applying to broken, irritated, or infected skin.
  • Keep out of reach of children.
  • Do not use if allergic to ketoprofen or other NSAIDs
  • Consult your doctor before use if you have a history of liver or kidney problems.
  • Remove the patch before undergoing MRI scans.

Site of Application

• Clean, dry skin – make sure the area is dry.
• Where to put it – upper arm, chest, or back.
• Don’t use on – broken, red, or scarred skin.

Dosage & Administration

• One patch to be applied and left in place for 24 hours.
• Follow your healthcare provider’s instructions for the duration of use.
• After 24 hours, remove the patch and apply a new one to a different skin site to avoid irritation.

Why Choose K-Plast Patch?

• 24-Hour Relief: One patch applied in the morning works all day and night.
• Safer Alternative: Bypasses the stomach and liver, reducing gastric irritation.
• Flexible & Reversible: Simply remove the patch to stop therapy.
• Patient-Friendly: Ideal for those who have trouble swallowing pills.
• Made for Indian Conditions: Hot Melt Technology ensures the patch stays secure even in heat and humidity.

Active Ingredient:Ketoprofen 30 mg per patch

Mechanism of Action:

• Inhibits COX enzymes, reducing prostaglandin synthesis to decrease inflammation and pain.
• Transdermal delivery provides steady plasma drug levels over 24 hours, avoiding peaks and troughs seen with oral therapy.
• Minimizes gastrointestinal irritation and systemic exposure.

Indications:

• Post-operative pain management
• Chronic low back pain
• Sprains, strains, and traumatic injuries
• Muscle spasms and localized inflammatory conditions
• Patients requiring continuous analgesia or unable to take oral therapy

Dosage & Administration:

• Monitor for skin reactions; discontinue if severe irritation occurs.
• Can be combined with other analgesics if additional pain control is needed, considering total NSAID exposure.
• No further NRT required after completion

Site of Application:

Apply on clean, dry, hairless skin of the upper arm, back, or chest; avoid broken, irritated, or scarred area

Pharmacokinetics:

• Absorption: Gradual and controlled through the skin over 24 hours.
• Distribution: Maintains uniform plasma concentrations.
• Metabolism: Minimal first-pass hepatic metabolism.
• Excretion: Primarily renal.

Contraindications:

• Do not use if allergic to ketoprofen or other NSAIDs
• Avoid in patients with active stomach ulcers, bleeding, or serious GI problems
• Avoid in severe liver, kidney, or heart disease
• Use with caution in asthma or NSAID-sensitive patients
• Pregnancy or breastfeeding: only if benefits outweigh risks

Clinical Evidence:

• Comparable efficacy to oral ketoprofen for pain relief in post-operative, musculoskeletal, and dental pain.
• Reduced gastrointestinal and systemic side effects versus oral NSAIDs.
• Hot Melt Technology ensures superior patch adhesion and consistent drug delivery.
• Studies report high patient adherence due to 24-hour sustained release and ease of use.

Storage & Handling

• Store at room temperature, ≤25°C, in a dry area.
• Avoid direct sunlight, heat, and moisture.
• Discard damaged patches responsibly.

Supporting Tools & Resources

• Patient leaflets with application instructions.
• Pain tracking charts to monitor therapy progress.
• Clinic posters to encourage proper patch use and adherence.
• MantraBot: Supports reminders, adherence tracking, and post-therapy guidance.